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Modifying the Registry, Using GPO to Disable Adobe Flash in Internet Explorer

You can disable attempts to instantiate Adobe Flash Player in Internet Explorer and other applications that honor the kill bit feature, such as Office 2007 and Office 2010, by setting the kill bit for the control in the registry. If you need to disable Adobe Flash on PCs running Internet Explorer, save the following as a text file with a .reg extension…

Windows Registry Editor Version 5.00
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Internet Explorer\ActiveX Compatibility\{D27CDB6E-AE6D-11CF-96B8-444553540000}]
“Compatibility Flags”=dword:00000400
[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Microsoft\Internet Explorer\ActiveX Compatibility\{D27CDB6E-AE6D-11CF-96B8-444553540000}]
“Compatibility Flags”=dword:00000400
You can also apply this workaround across domains by using Group Policy. Internet Explorer needs to be restarted for the changes to take effect.

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