I’ve seen this issue show up a on a few refreshes if the users have custom add-ins to excel. Not sure of the exact cause per-say and how to avoid it quite yet, but at least it’s a simple issue to resolve. If the users are getting a “c:\program.xls” cannot be found, followed by a bunch of other excel errors, then you need to go to the HKCU registry and modify a few things. If you look at the errors you’ll see what is going on, basically the path is getting cut off and producing multiple errors.
Here are some examples:
One solution that works is to do a detect and repair in office and discard any settings. this will “kill” any add-ins and thus resolve the issue. However, rather than resetting office settings, here is a solution for this error and similar errors… this way you fix the issue without losing user data…
Open regedit.exe and go to:
For each Addin that has a Name of "OPEN#"; for example, OPEN, OPEN1, OPENn. You will want to make sure the Addin’s have double quotes ("") around the Addin path.
Once you do that, open excel again, and the errors should be gone.