When planning a Configuration Manager 2012 environment it is wise to also plan the anti-virus scan exclusions for the servers. Adding exclusions to your anti-virus solution will give you a better performance, since the online access scanner will not scan every logfile or file in the Configuration Manager inbox folders. Based on the Configuration Manager 2007 blog of the ConfigMgr Team with the knowledge of Configuration Manager 2012 I created the exclusion list below, feel free to supply information if you are missing something.
Read the complete blog here: http://www.systemcenterblog.nl/2012/05/09/anti-virus-scan-exclusions-for-configuration-manager-2012/
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