Have you ever had to move any of the following system databases: master, tempdb and/or msdb to another location?
Be sure that you have a recent backup (use the backup task, which gives you all the information needed for recovery) for ConfigMgr.
You'll want to check the online reference for step by step instructions:
This topic describes how to move system databases in SQL Server. Moving system databases may be useful in the following situations:
- Failure recovery. For example, the database is in suspect mode or has shut down because of a hardware failure.
- Planned relocation.
- Relocation for scheduled disk maintenance
http://msdn.microsoft.com/en-us/library/ms345408.aspx