Ok, this is a really stupid one. Before installing the self service portal I opened up IIS and made sure nothing was running on port 80, because this was the port I wanted to use. But the Self Service Portal still ended with an error: An error
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Read the complete post at http://scug.be/blogs/valerie/archive/2011/12/01/scsm-2012-self-service-portal-setup-can-t-create-a-new-site.aspx