I was really hoping that the new FRS replacement in R2 would work to keep clusters in sync with each other. Apparently not. It does look like a huge improvement over the current FRS but it would have helped me out with a current disaster recovery project if they would have made it smart enough to work with clusters.
http://technet2.microsoft.com/WindowsServer/en/Library/b21366bd-d2a1-4bfb-b6f9-55dd5106b31d1033.mspx
On server clusters, replicated folders must be located in the local storage of a node because the DFS Replication service is not designed to work in a coordinated way with cluster components, and the service will not fail over to another node.
There's a decent video on some of the features of the new DFS Replication that comes with R2. One of the cool things they touch on is that the differential copies (only copying differences in files) will work for “new” files in some cases. For instance, if someone does a SaveAs on an existing file, DFSR is smart enough to recognize that and use the original file as a base and only copy the differences between the new file and the one that is already on the other link target replicas. Although I suppose I shouldn't call it a link target anymore since they've changed all of the terminology on us.