If you're interested in Configuration Manager native mode sites supporting Internet-based clients, you should definitely give this post a good read I think. It's an awesome post from Carol (our native mode/Internet-based client support writer (among other things)) on our writing team's blog:
http://blogs.technet.com/wemd_ua_-_sms_writing_team/archive/2008/01/15/tips-tricks-hints-for-native-mode-and-internet-based-client-management-part-1-of-3.aspx
~Jeff