McAfee's just-released 4833 DAT is identifying KevlarSigs.DLL in the System32 directory as Generic PUP.b. There is an extra dat already available, and the 4834 DAT's should be released later today to resolve the issue completely.
What is KevlarSigs.DLL, you might ask? Why, that would be a DLL installed by McAfee's own Host Intrusion Prevention System 6.0, aka HIPS or "kevlar".
Oh, the irony.